Nucleotide 9-mers characterize the type II diabetic gut metagenome.
Identifieur interne : 001088 ( Main/Exploration ); précédent : 001087; suivant : 001089Nucleotide 9-mers characterize the type II diabetic gut metagenome.
Auteurs : Balázs Szalkai [Hongrie] ; Vince Grolmusz [Hongrie]Source :
- Genomics [ 1089-8646 ] ; 2016.
Descripteurs français
- KwdFr :
- MESH :
- isolement et purification : Nucléotides.
- microbiologie : Diabète de type 2, Maigreur, Obésité, Tube digestif.
- Femelle, Humains, Marqueurs biologiques, Microbiome gastro-intestinal, Mâle, Métagénome, Nucléotides, Études cas-témoins.
English descriptors
- KwdEn :
- Biomarkers (chemistry), Case-Control Studies, Diabetes Mellitus, Type 2 (microbiology), Female, Gastrointestinal Microbiome, Gastrointestinal Tract (microbiology), Humans, Male, Metagenome, Nucleotides (chemistry), Nucleotides (isolation & purification), Obesity (microbiology), Thinness (microbiology).
- MESH :
- chemical , chemistry : Biomarkers, Nucleotides.
- chemical , isolation & purification : Nucleotides.
- microbiology : Diabetes Mellitus, Type 2, Gastrointestinal Tract, Obesity, Thinness.
- Case-Control Studies, Female, Gastrointestinal Microbiome, Humans, Male, Metagenome.
Abstract
Discoveries of new biomarkers for frequently occurring diseases are of special importance in today's medicine. While fully developed type II diabetes (T2D) can be detected easily, the early identification of high risk individuals is an area of interest in T2D, too. Metagenomic analysis of the human bacterial flora has shown subtle changes in diabetic patients, but no specific microbes are known to cause or promote the disease. Moderate changes were also detected in the microbial gene composition of the metagenomes of diabetic patients, but again, no specific gene was found that is present in disease-related and missing in healthy metagenome. However, these fine differences in microbial taxon- and gene composition are difficult to apply as quantitative biomarkers for diagnosing or predicting type II diabetes. In the present work we report some nucleotide 9-mers with significantly differing frequencies in diabetic and healthy intestinal flora. To our knowledge, it is the first time such short DNA fragments have been associated with T2D. The automated, quantitative analysis of the frequencies of short nucleotide sequences seems to be more feasible than accurate phylogenetic and functional analysis, and thus it might be a promising direction of diagnostic research.
DOI: 10.1016/j.ygeno.2016.02.007
PubMed: 26945643
Affiliations:
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Electronic address: grolmusz@pitgroup.org.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>PIT Bioinformatics Group, Eötvös University, H-1117 Budapest, Hungary; Uratim Ltd., H-1118 Budapest</wicri:regionArea><wicri:noRegion>H-1118 Budapest</wicri:noRegion></affiliation></author></analytic><series><title level="j">Genomics</title><idno type="eISSN">1089-8646</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Biomarkers (chemistry)</term><term>Case-Control Studies</term><term>Diabetes Mellitus, Type 2 (microbiology)</term><term>Female</term><term>Gastrointestinal Microbiome</term><term>Gastrointestinal Tract (microbiology)</term><term>Humans</term><term>Male</term><term>Metagenome</term><term>Nucleotides (chemistry)</term><term>Nucleotides (isolation & purification)</term><term>Obesity (microbiology)</term><term>Thinness (microbiology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Diabète de type 2 (microbiologie)</term><term>Femelle</term><term>Humains</term><term>Maigreur (microbiologie)</term><term>Marqueurs biologiques ()</term><term>Microbiome gastro-intestinal</term><term>Mâle</term><term>Métagénome</term><term>Nucléotides ()</term><term>Nucléotides (isolement et purification)</term><term>Obésité (microbiologie)</term><term>Tube digestif (microbiologie)</term><term>Études cas-témoins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Biomarkers</term><term>Nucleotides</term></keywords><keywords scheme="MESH" type="chemical" qualifier="isolation & purification" xml:lang="en"><term>Nucleotides</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Nucléotides</term></keywords><keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Diabète de type 2</term><term>Maigreur</term><term>Obésité</term><term>Tube digestif</term></keywords><keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Diabetes Mellitus, Type 2</term><term>Gastrointestinal Tract</term><term>Obesity</term><term>Thinness</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Case-Control Studies</term><term>Female</term><term>Gastrointestinal Microbiome</term><term>Humans</term><term>Male</term><term>Metagenome</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Femelle</term><term>Humains</term><term>Marqueurs biologiques</term><term>Microbiome gastro-intestinal</term><term>Mâle</term><term>Métagénome</term><term>Nucléotides</term><term>Études cas-témoins</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Discoveries of new biomarkers for frequently occurring diseases are of special importance in today's medicine. While fully developed type II diabetes (T2D) can be detected easily, the early identification of high risk individuals is an area of interest in T2D, too. Metagenomic analysis of the human bacterial flora has shown subtle changes in diabetic patients, but no specific microbes are known to cause or promote the disease. Moderate changes were also detected in the microbial gene composition of the metagenomes of diabetic patients, but again, no specific gene was found that is present in disease-related and missing in healthy metagenome. However, these fine differences in microbial taxon- and gene composition are difficult to apply as quantitative biomarkers for diagnosing or predicting type II diabetes. In the present work we report some nucleotide 9-mers with significantly differing frequencies in diabetic and healthy intestinal flora. To our knowledge, it is the first time such short DNA fragments have been associated with T2D. The automated, quantitative analysis of the frequencies of short nucleotide sequences seems to be more feasible than accurate phylogenetic and functional analysis, and thus it might be a promising direction of diagnostic research. </div></front></TEI><affiliations><list><country><li>Hongrie</li></country></list><tree><country name="Hongrie"><noRegion><name sortKey="Szalkai, Balazs" sort="Szalkai, Balazs" uniqKey="Szalkai B" first="Balázs" last="Szalkai">Balázs Szalkai</name></noRegion><name sortKey="Grolmusz, Vince" sort="Grolmusz, Vince" uniqKey="Grolmusz V" first="Vince" last="Grolmusz">Vince Grolmusz</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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